可以尝试使用React hooks中的useMemo来缓存GraphQL操作，并根据变量的更改条件重新调用缓存的操作。从而实现在变量更改时也能重新查询数据。

代码示例如下：

import { useMemo } from 'react';
import { useQuery } from '@apollo/client';
import { graphql } from 'relay-runtime';
import { relayStylePagination } from '@apollo/client/utilities';

const QUERY = graphql`
  query MyQuery($first: Int!, $after: String) {
    items: myQuery(first: $first, after: $after) @connection(key: "myQuery_items") {
      edges {
        node {
          id
          name
        }
      }
      pageInfo {
        endCursor
        hasNextPage
      }
    }
  }
`;

function MyComponent(props) {
  const { first, after } = props;
  
  const queryVariables = useMemo(() => ({ first, after }), [first, after]);

  const { loading, error, data, fetchMore } = useQuery(QUERY, {
    variables: queryVariables,
    fetchPolicy: 'cache-and-network',
    notifyOnNetworkStatusChange: true,
  });

  const loadedData = data?.items?.edges?.map(edge => edge.node) ?? [];
  const pageInfo = data?.items?.pageInfo;

  const fetchMoreData = () => {
    if (!pageInfo?.hasNextPage) return;
    const { endCursor } = pageInfo;

    fetchMore({
      variables: { after: endCursor },
      updateQuery: (prevResult, { fetchMoreResult }) => {
        return relayStylePagination([...prevResult?.items?.edges, ...fetchMoreResult?.items?.edges], fetchMoreResult?.items?.pageInfo, prevResult);
      }
    });
  };

  // your component render code here...
}

在这个示例中，我们使用缓存的GraphQL操作，并在useMemo函数中将变量作为依赖条件。使用fetchMore来在查询结果后继续获取数据，并使用relayStylePagination更新查询结果。

通过这种方法，可以在变量更改时重新获取